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Description
Human YWHAG/14-3-3 gamma Protein, His TagProduct Specification Species Human Synonyms 14 3 3 protein gamma, Protein kinase C inhibitor protein 1 (KCIP 1) Accession P61981 Amino Acid Sequence Protein sequence (P61981, Met1 Asn247, with C His Tag) MVDREQLVQKARLAEQAERYDDMAAAMKNVTELNEPLSNEERNLLSVAYKNVVGARRSSWRVISSIEQKTSADGNEKKIEMVRAYREKIEKELEAVCQDVLSLLDNYLIKNCSETQYESKVFYLKMKGDYYRYLAEVATGEKRATVVESSEKAYSEAHEISKEHMQPTHPIRLGLALNYSVFYYEIQNAPEQACHLAKTAFDDAIAELDTLNEDSYKDSTLIMQLLRDNLTLWTSDQQDDDGGEGNN
Product Specification
| Species | Human |
| Synonyms | 14-3-3 protein gamma, Protein kinase C inhibitor protein 1 (KCIP-1) |
| Accession | P61981 |
| Amino Acid Sequence | Protein sequence (P61981, Met1-Asn247, with C-His Tag) MVDREQLVQKARLAEQAERYDDMAAAMKNVTELNEPLSNEERNLLSVAYKNVVGARRSSWRVISSIEQKTSADGNEKKIEMVRAYREKIEKELEAVCQDVLSLLDNYLIKNCSETQYESKVFYLKMKGDYYRYLAEVATGEKRATVVESSEKAYSEAHEISKEHMQPTHPIRLGLALNYSVFYYEIQNAPEQACHLAKTAFDDAIAELDTLNEDSYKDSTLIMQLLRDNLTLWTSDQQDDDGGEGNN |
| Expression System | E.coli |
| Molecular Weight | Predicted MW: 30 kDa Observed MW: 30 kDa |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <1EU/μg |
| Conjugation | Unconjugated |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4 with 3% trehalose. |
| Reconstitution | Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation. |
| Stability & Storage | 12 months from date of receipt, -20 to -70 °C as supplied. |
Background
The 14-3-3 protein gamma (YWHAG) is a crucial member of the highly conserved 14-3-3 protein family, which is ubiquitously expressed in eukaryotic cells. It functions as a key regulatory module by binding to client proteins that are phosphorylated on specific serine or threonine residues. Through these interactions, 14-3-3 gamma modulates a wide array of vital cellular processes, including signal transduction, cell cycle control, apoptosis, and neuronal development. It acts by inducing conformational changes in its targets, altering their subcellular localization, stability, or enzymatic activity. Dysregulation of 14-3-3 gamma is implicated in various human diseases, notably cancer and neurological disorders.
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